The Brain That Wouldn't Die

The Brain That Wouldn't Die is a 1962 American science fiction horror film that focuses upon a mad doctor who develops a means to keep human body parts alive. He keeps his fiancée's severed head alive for days, and also keeps a lumbering, malformed brute (one of his earlier failed experiments) imprisoned in a closet.

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A doctor experimenting with transplant techniques keeps his girlfriend's head alive when she is decapitated in a car crash, then goes hunting for a new body.